Evaluation of Plasma Concentrations of Intravenous Lidocaine and Epidural Ropivacaine When Used in Combination in Major Abdominal Surgery

Summary

Thoracic epidural analgesia (TEA) is the gold standard analgesia of the laparotomy in major abdominal surgery and can be associated with intravenous lidocaine or subtituted by intravenous lidocaine when TEA is contraindicated and in order to reduce the use of the morphinics in the perioperative period. Side effects can be paralytic ileus or nausea and vomiting and delay the enhanced recovery after surgery. Intravenous lidocaine and TEA share several properties like anti hyperalgesia, anti inflammatory effect, intestinal process, anti tumoral effect… which suggests an additive effect of their combination that was not studied yet.

Timeline

Start

2022-03-09

Primary completion

2024-01-28

Completion

2024-10-02

Publications

• Trocheris-Fumery O, Pruvot A, Tarpin P, Collette S, Bodeau S, Diouf M, Regimbeau JM, Dupont H, Bar S, Bennis Y, Abou-Arab O. A prospective observational study of plasma concentrations and safety of combined intravenous lidocaine and epidural ropivacaine in laparotomy surgery. PLoS One. 2026 Mar 6;21(3):e0344277. doi: 10.1371/journal.pone.0344277. eCollection 2026.

Drugs

Indications

No indication recorded.