drugset / Trial / NCT05378919
Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer
RandomizedParallel-groupOpen-labelTreatment
Summary
Phase II, Multicenter, Open-label, Randomized Study evaluating neoadjuvant chemotherapy (FOLFOX4) in patients with stage II and III colorectal cancer with standard chemoradiation Defined by Magnetic Resonance Imaging
Timeline
- Start
- 2015-06-01
- Primary completion
- 2025-06-01
- Completion
- 2027-06-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Oxaliplatin | Small molecule | 85 mg/m2 | — |
| Comparator | fluorouracil | Small molecule | 400 mg/m2 | — |
| Comparator | fluorouracil | Small molecule | 600 mg/m2 | — |
| Background | Leucovorin | Small molecule | 100 mg/m2 | — |
| Comparator | folic acid | Other / unclassified | 20 mg/m2 | — |
Indications
No indication recorded.