drugset / Trial / NCT05384015

Study of Pembrolizumab, Lenvatinib and Chemotherapy Combination in First Line Extensive-stage Small Cell Lung Cancer

NCT05384015 ↗

Phase 2 Active not recruiting 46 enrolled Fundación GECP
NaSingle-groupOpen-labelTreatment

Summary

This is a multicenter, open-label, non-randomized, single arm, 2 parts, phase II clinical trial evaluating the efficacy and safety of pembrolizumab and lenvatinib plus standard of care chemotherapy (with carboplatin and etoposide ) in subjects with histologically confirmed extensive-stage small-cell lung cancer who have not previously received systemic therapy for this malignancy.

Timeline

Start
2022-11-07
Primary completion
2027-07-30
Completion
2027-12-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Lenvatinib Small molecule 20 mg Oral
Subject Pembrolizumab Monoclonal antibody 200 mg Intravenous
Background Carboplatin Small molecule 5 unknown Intravenous
Background Etoposide Small molecule 100 mg/m2 Intravenous