The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers

Summary

The aim of this study is to evaluate the Popliteal Plexus Block (PPB) effect on motor nerve branches of the sciatic and femoral nerve, when using different volumes of local anesthetics for PPB. The hypothesis is that increasing the volume of anesthetics used for PPB will spread to the sciatic nerve leading to a reduced muscle strength in the lower leg and decreased nerve conduction velocity in the nerve to gastrocnemius muscle (the tibial nerve) and the nerve to anterior tibial muscle (the deep fibular nerve). The effects will be evaluated by maximum voluntary isometric contraction (MVIC) of the lower leg muscles and by recordings of the compound muscle action potential (cMAP) of the gastrocnemius and tibialis anterior muscles - a motor nerve conduction study. In addition, evaluation of PPBs effect on the femoral nerve is done by MVIC of the quadriceps femoris muscle, cMAP of the vastus medialis and vastus lateralis muscles and by a sensory nerve conduction study of the saphenous nerve.

Timeline

Start

2023-09-29

Primary completion

2023-10-19

Completion

2023-10-19

Outcome

Missed primary endpoint

paper There were no significant differences in motor function between the three PPB groups for any MVIC measures (p≥0.1). PMID 40185510 ↗

Publications

• Sorensen JK, Grevstad U, Qerama E, Bruun LS, Nikolajsen L, Runge C. Effect of local anesthetic volume for popliteal plexus block on motor nerve conduction and muscle function in the leg: a randomized clinical trial in healthy volunteers. Reg Anesth Pain Med. 2025 Apr 3:rapm-2025-106557. doi: 10.1136/rapm-2025-106557. Online ahead of print.

Drugs

Indications