Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients

Phase 4 Unknown 100 enrolled The First Affiliated Hospital with Nanjing Medical University

RandomizedParallel-groupDouble-blindTreatment

Summary

A prospective, randomized controlled study was conducted to compare the effects of esketamine combined with dexmedetomidine in the sedation and analgesia treatment of mechanically ventilated patients in the ICU on the time to awaken, time to extubation, time to mechanical ventilation, time in the ICU, and on delirium.

Timeline

Start: 2022-08-11
Primary completion: 2024-12-01
Completion: 2024-12-01

Publications

Zhang W, You J, Hu J, Chen X, Wang H, Li N, Wei C, Tang W, Zuo X. Effect of esketamine combined with dexmedetomidine on delirium in sedation for mechanically ventilated ICU patients: protocol for a nested substudy within a randomized controlled trial. Trials. 2024 Jul 2;25(1):431. doi: 10.1186/s13063-024-08287-3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dexmedetomidine	Other / unclassified	0.2 mg/kg	Intravenous
Comparator	Dexmedetomidine	Other / unclassified	0.7 mg/kg	Intravenous
Subject	Esketamine	Other / unclassified	0.25 mg/kg	Intravenous
Subject	Esketamine	Other / unclassified	1.5 mg/kg	Intravenous

Indications

No indication recorded.