Ondansetron for Postspinal Anesthesia Hypotension

Summary

The purpose of this study is to investigate the effectiveness of ondansetron for postspinal anesthesia hypotension in patients undergoing cesarean section.

Timeline

Start

2023-06-18

Primary completion

2023-10-27

Completion

2023-10-27

Outcome

Met primary endpoint

paper The primary outcomes (median performance error, MDPE and median absolute performance error, MDAPE) were significantly different among the three groups. (p = 0.001, p = 0.002). PMID 40248081 ↗

paper Compared with the NS group, systolic blood pressure (SBP) was maintained closer to baseline in the 4 mg group (p = 0.003, p = 0.006), PMID 40248081 ↗

Publications

• Qin R, Xu X, Zhao N, Shi Y, Chen Y, Chen J, Ni X. Effect of different prophylactical doses of ondansetron for the hemodynamic stability in patients undergoing cesarean section: a randomized controlled study. Front Med (Lausanne). 2025 Apr 3;12:1495721. doi: 10.3389/fmed.2025.1495721. eCollection 2025.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ondansetron	Other / unclassified	4 mg	Intravenous
Subject	Ondansetron	Other / unclassified	8 mg	Intravenous

Indications

No indication recorded.