A Study to Examine the Effect of Daridorexant on the Way the Body Absorbs, Distributes, and Gets Rid of Midazolam and Warfarin in Healthy Male Subjects

Phase 1 Completed 18 enrolled Idorsia Pharmaceuticals Ltd.

NaSequentialOpen-labelOther

Summary

A study to examine the effect of daridorexant on the way the body absorbs, distributes, and gets rid of midazolam and warfarin in healthy male subjects

Timeline

Start: 2022-08-23
Primary completion: 2022-09-23
Completion: 2022-10-06

Publications

Zenklusen I, Dingemanse J, Reh C, Gehin M, Kaufmann P. Effect of Daridorexant on the Pharmacokinetics of Midazolam, and on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Male Subjects. Drugs R D. 2024 Mar;24(1):97-108. doi: 10.1007/s40268-024-00456-8. Epub 2024 Mar 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Daridorexant	Small molecule	50 mg	Oral
Subject	Midazolam	Small molecule	2 mg	Oral
Subject	Warfarin	Small molecule	25 mg	Oral

Indications

No indication recorded.