Neural Correlates of Lidocaine Analgesia

Phase 1 Completed 30 enrolled Keith M Vogt National Institute of General Medical Sciences (NIGMS) · collab

NaSingle-groupOpen-labelBasic science

Summary

The purpose of this study is to characterize the effects of intravenous lidocaine on pain processing and cognitive function. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will consist of 1 visit and involves no long-term follow up.

Timeline

Start: 2022-11-22
Primary completion: 2023-11-17
Completion: 2023-11-17

Publications

Vogt KM, Burlew AC, Simmons MA, Reddy SN, Kozdron CN, Ibinson JW. Neural correlates of systemic lidocaine administration in healthy adults measured by functional MRI: a single arm open label study. Br J Anaesth. 2025 Feb;134(2):414-424. doi: 10.1016/j.bja.2024.07.039. Epub 2024 Oct 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	—	Intravenous

Indications

No indication recorded.