drugset / Trial / NCT05508594
Efficacy and Pharmacokinetic-Pharmacodynamic Relationship of Intranasally Administered Sufentanil, Ketamine, and CT001
RandomizedParallel-groupQuadruple-blindTreatment
Summary
A randomised, double-blind, parallel-group, study comparing the analgesic effect of intranasal CT001 to intranasal sufentanil, intranasal ketamine or placebo for treatment of acute pain in adults undergoing surgical removal of an impacted mandibular third molar, where bone removal is judged to be needed.
Timeline
- Start
- 2022-09-05
- Primary completion
- 2023-10-05
- Completion
- 2023-10-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | CT001 | Unknown | — | Intranasal |
| Comparator | Ketamine | Small molecule | 13 mg | Intranasal |
| Comparator | Ketamine | Small molecule | 27 mg | Intranasal |
| Comparator | Ketamine | Small molecule | 40 mg | Intranasal |
| Comparator | Sufentanil | Other / unclassified | 13 ug | Intranasal |
| Comparator | Sufentanil | Other / unclassified | 27 ug | Intranasal |
| Comparator | Sufentanil | Other / unclassified | 40 ug | Intranasal |
Indications
No indication recorded.