drugset / Trial / NCT05510089
Etoposide+Cytarabine+PEG-rhG-CSF for Hematopoietic Stem Cell Mobilization in Patients With Hematological Malignancies
NaSingle-groupOpen-labelTreatment
Summary
This is a single-arm, multicenter, exploratory clinical study to evaluate the safety and efficacy of the combination of etoposide, cytarabine and PEG-rhG-CSF (EAP regimen) on hematopoietic stem cell mobilization in poor mobilization patients with hematological malignancies. All eligible patients will receive EAP regimen treatment, then the number of CD34+ cells and white blood cells will be monitoring. When the collection standard is met, hematopoietic stem cell collection will be started.
Timeline
- Start
- 2022-09-01
- Primary completion
- 2024-05-31
- Completion
- 2024-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cytarabine | Small molecule | 300 mg/m2 | — |
| Subject | Etoposide | Small molecule | 75 mg/m2 | — |
| Subject | Pegfilgrastim | Protein / enzyme biologic | 6 mg | — |