Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents

Summary

Evalaution of clinical success of secondary treatment for total 40 permanent incisors with failed root canal treatment with apical radiolucency. Twenty of of these permanent incisors will be treated with regenerative endodontic treatment(RET) with platelets rich fibrin PRF as intervention group vs. 20 incisors control group secondary treated with (RET) with induced blood clot (BC).

Timeline

Start

2022-03-10

Primary completion

2023-03-01

Completion

2023-03-01

Publications

• Sermani DI, Abdelmotelb MA, Elheeny AAH. Postoperative pain after pulpotomy versus pulpectomy of primary molars with symptomatic irreversible pulpitis: an equivalent randomized clinical trial. BMC Oral Health. 2026 Apr 25;26(1):786. doi: 10.1186/s12903-026-08329-z.

Drugs

Indications