drugset / Trial / NCT05534750
Evaluation of the Early Bactericidal Activity of Tedizolid and Linezolide Against Mycobacterium Tuberculosis (TEDITUB)
RandomizedParallel-groupOpen-labelTreatment
Summary
The objective of this work is to measure the early bactericidal activity of tedizolid, to compare it with the bactericidal activity of linezolid (reference molecule for the treatment of multidrug-resistant tuberculosis) and with that of standard quadruple therapy (reference treatment of drug susceptible tuberculosis).
Timeline
- Start
- 2023-04-20
- Primary completion
- 2026-04
- Completion
- 2026-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ethambutol | Small molecule | — | — |
| Comparator | Isoniazid | Small molecule | 5 mg/kg | — |
| Subject | Linezolid | Other / unclassified | 600 mg | — |
| Comparator | Pyrazinamide | Small molecule | — | — |
| Comparator | Rifampin | Small molecule | 10 mg/kg | — |
| Subject | Tedizolid | Small molecule | 200 mg | — |