drugset / Trial / NCT05536154

Etoposide+Cytarabine+PEG-rhG-CSF as First Line Mobilization Regimen of Hematopoietic Stem Cells in Patients With Hematological Malignancies

NCT05536154

NaSingle-groupOpen-labelTreatment

Summary

This is a single-arm, multicenter, exploratory clinical study to evaluate the safety and efficacy of the combination of etoposide, cytarabine and PEG-rhG-CSF (EAP regimen) as first line mobilization regimen of hematopoietic stem cells in patients with lymphoma and multiple myeloma. All eligible patients will receive EAP regimen treatment, then the number of CD34+ cells and white blood cells will be monitoring. When the collection standard is met, hematopoietic stem cell collection will be started.

Timeline

Start
2022-11-01
Primary completion
2024-06
Completion
2024-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Cytarabine Small molecule 200 mg/m2
Subject Etoposide Small molecule 75 mg/m2
Subject Pegfilgrastim Protein / enzyme biologic 6 mg

Indications