drugset / Trial / NCT05536570

Whiplash-induced Thoracic Outlet Syndrome Treated With Botulinum Toxin.

NCT05536570 ↗

Phase 4 Unknown 15 enrolled King, David, MD MERZ PHARMA · collab
Non-randomizedSingle-groupOpen-labelTreatment

Summary

Whiplash injuries following car accident are common, it has been reported to affect 83% of individuals injured in traffic collisions (Yadla S, 2007). The condition is caused by a rapid acceleration followed immediately by a rapid deceleration of the neck and head. The annual North American incidence rate is estimated to be 600 per 100,000 people (Holm LW, 2008). The condition is costly for society and disabling/painful for the patients. Depending on the collision type, the biomechanics of muscles will be affected differently and consequently the clinical presentation will vary. T-bone type of car collisions (when the front of one vehicle strikes the side of another) may induce thoracic outlet syndrome (TOS) following compression on the nerve and artery bundle by the scalene muscles (lateral stabilizers of the neck). An appropriate and detailed examination of the patient is necessary to identify the cause of the resulting pain and disability. Once a functional thoracic outlet syndrome is identified the proposal is to treat this with botulinum toxin.

Timeline

Start
2022-10-15
Primary completion
2023-04-15
Completion
2023-06-15

Drugs

EvaluationDrugModalityDoseRoute
Subject Botulinum toxin type A Protein / enzyme biologic 100 unknown Intramuscular