Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali

Summary

The purpose of this study is to compare the gametocytocidal and transmission reducing activity of artesunate-amodiaquine (ASAQ) and artemether-lumefantrine-amodiaquine (ALAQ) with and without a single dose of 0.25mg/kg primaquine (PQ). Outcome measures will include infectivity to mosquitoes at 2, 7 and 14 days after treatment, gametocyte density throughout follow-up, and safety measures including haemoglobin density and the frequency of adverse events.

Timeline

Start

2022-10-17

Primary completion

2022-12-30

Completion

2023-01-26

Publications

• Mahamar A, Vanheer LN, Smit MJ, Sanogo K, Sinaba Y, Niambele SM, Diallo M, Dicko OM, Diarra RS, Maguiraga SO, Youssouf A, Sacko A, Keita S, Samake S, Dembele A, Teelen K, Dicko Y, Traore SF, Dondorp A, Drakeley C, Stone W, Dicko A. Artemether-lumefantrine-amodiaquine or artesunate-amodiaquine combined with single low-dose primaquine to reduce Plasmodium falciparum malaria transmission in Ouelessebougou, Mali: a five-arm, phase 2, single-blind, randomised controlled trial. Lancet Microbe. 2025 Feb;6(2):100966. doi: 10.1016/j.lanmic.2024.100966. Epub 2024 Dec 17.

Drugs

Indications