drugset / Trial / NCT05551949
Preventing Recurrent UTI With Vaginal Estrogen
Phase 4
Completed
27 enrolled
Johns Hopkins University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collabUniversity of Maryland · collab
NaSingle-groupOpen-labelPrevention
Summary
Among postmenopausal women who suffer from recurrent urinary tract infections (UTI), vaginal estrogen therapy prevents UTI recurrences for 50% of sufferers. This research will investigate why some women benefit but others do not, focusing on (a) the effects of vaginal estrogen therapy on the bacteria that inhabit the vagina and bladder, (b) its influence on immune responses in both compartments, and (c) the extent to which those changes are critical to successful UTI prevention. The findings will be a first step in the development of more effective strategies to prevent UTI, one of the most common and costly benign urologic conditions.
Timeline
- Start
- 2022-01-01
- Primary completion
- 2025-06-30
- Completion
- 2025-08-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Estradiol | Other / unclassified | 10 ug | Other |