Effects of Denosumab on Bone Microarchitecture After Total Knee Arthroplasty

Summary

This study evaluates single dose of Denosumab in decreasing systemic and periprosthetic bone resorption after Total Knee Arthroplasty compared to placebo in 60 patients (30 placebo and 30 Denosumab) within 2 months after surgery. This study also evaluates the anti-RANKL effect of single dose of Denosumab in serum, skeletal muscle, synovium, fat, and cartilage.

Timeline

Start

2022-10-01

Primary completion

2023-12-31

Completion

2023-12-31

Drugs

Indications