drugset / Trial / NCT05561673

A Study on the Safety and Immune Response of AS37 Together With Hepatitis B Antigen in Adults Aged 18-45 Years

NCT05561673

Phase 1 Completed 122 enrolled GlaxoSmithKline
RandomizedParallel-groupOpen-labelPrevention

Summary

This study is conducted to assess safety and immunogenicity of GSK's HBsAg vaccine adjuvanted with GSK's AS37 adjuvant system in healthy, HBs naïve, adults aged 18-45 years and to differentiate GSK's AS37 adjuvant system from other approved adjuvant systems and from an aluminum-based adjuvant.

Timeline

Start
2022-10-04
Primary completion
2024-11-29
Completion
2024-11-29

Drugs

EvaluationDrugModalityDoseRoute
Subject AS03 Other / unclassified Intramuscular
Subject AS04 Unknown Intramuscular
Subject AS37A Unknown 100 ug Intramuscular
Subject AS37B Unknown 50 ug Intramuscular
Subject GSK's HBsAg (20 μg) vaccine adjuvanted with GSK's AS37A adjuvant system (100 μg) Vaccine 20 ug Intramuscular
Subject GSK's HBsAg (20 μg) vaccine adjuvanted with GSK's AS37B adjuvant system (50 μg) Vaccine 20 ug Intramuscular
Subject HBsAg candidate vaccine Vaccine Intramuscular
Subject Hepatitis B vaccine Vaccine Intramuscular
Background Aluminum hydroxide Unknown Intramuscular