Bicarbonate for In-Hospital Cardiac Arrest

Summary

This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of sodium bicarbonate during adult in-hospital cardiac arrest. There will be 22 enrolling sites in Denmark. 778 adult patients with in-hospital cardiac arrest receiving at least one dose of adrenaline will be enrolled. The primary outcome is return of spontaneous circulation and key secondary outcomes include survival at 30 days and survival at 30 days with a favorable neurological outcome.

Timeline

Start

2023-02-06

Primary completion

2026-02-11

Completion

2027-02-11

Publications

• Granfeldt A, Kirkegaard BL, Vallentin MF, Holmberg MJ, Stankovic N, Lind PC, Kjaergaard AG, Houe N, Vested M, Isbye DL, Kristensen CM, Kjaergaard J, Zwisler ST, Lundsfryd SN, Petersen LB, Folke F, Hansen CM, Iversen KK, Schou M, Wiberg S, Riddersholm SJ, Rasmussen BS, Karlsson K, Plovsing RR, Juhl CS, Krag M, Sorensen CD, Kuhne-Qvist P, Oxlund J, Solling CG, Hansen JR, Andersen LPK, Jensen JMS, Itenov TS, Lauritzen M, Pedersen MJ, Nielsen RP, Fjeldsoe-Nielsen H, Mirzada N, Secher N, Espelund US, Eskol JR, Andersen K, Brochner AC, Nedergaard HK, Hansen PM, Henschel W, Walli AR, Sandgaard M, Asferg CL, Ciubotariu A, Rasmussen MHR, Le Breton V, Nielsen LK, Hansen FG, Braendstrup N, Thomsen IK, Sindberg B, Andersen LW; Bicarbonate for In-Hospital Cardiac Arrest (BIHCA) Investigators. Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA. 2026 Jun 11:e2610628. doi: 10.1001/jama.2026.10628. Online ahead of print.

Drugs

Indications