Atorvastatin Efficacy and Safety in Patients With Ulcerative Colitis

Summary

Statins exert numerous pleiotropic effects including anti-inflammatory, antioxidant properties, endothelial function improvement, and immunomodulation independent of their basic lipid-lowering properties.

Timeline

Start

2023-02-01

Primary completion

2025-06-01

Completion

2025-06-01

Publications

• Khrieba MO, Abdulelah FM, Alsaleh NA, AlRasheed HA, Ahmed TI, El-Sayed Mansy A, Hamouda MA, Habba E, Elshorbagi N, Abd Elhameed AG, Hamza E, Salahuddin MM, Mourad SA, Kamal M. Atorvastatin as an immunomodulatory adjunct in ulcerative colitis, beyond lipid lowering to inflammation control: a randomized controlled pilot study. Front Pharmacol. 2025 Oct 29;16:1690513. doi: 10.3389/fphar.2025.1690513. eCollection 2025.

Drugs

Indications