NCT05589441: Nebulized Salbutamol Facilitate Management of Hyperkalemia Postreperfusion…

Summary

The therapeutic effect of nebulized salbutamol on hyperkalemia during reperfusion in liver transplantation patients. Secondary research objectives: To observe the results of blood gas analysis, changes in urinary potassium and hemodynamic parameters, and the incidence of reperfusion syndrome in liver transplantation, and to observe the incidence of postoperative pulmonary complications during the 7-day follow-up. To explore the effect of aerosol inhalation of salbutamol on new liver reperfusion syndrome in patients with liver transplantation, and to provide a theoretical basis for clinical treatment.

Timeline

Start: 2022-10-28
Primary completion: 2023-10-10
Completion: 2024-01-10

Outcome

Met primary endpoint

paper The incidence of hyperkalemia at Rep1 was significantly lower in Group B than in Group A (36% vs. 56%, P = 0.045). PMID 41565838 ↗

Publications

Ding Y, Wen J, Xiao Y. Comparison of nebulized salbutamol and glucose-insulin for preventing acute hyperkalemia in liver transplantation: a randomized, double-blind trial. J Anesth. 2026 Jan 21. doi: 10.1007/s00540-025-03643-2. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Insulin	Protein / enzyme biologic	8 iu	Intravenous
Subject	Salbutamol	Unknown	10 mg	Inhaled
Background	Glucose	Unknown	250 ml	Intravenous

Indications