drugset / Trial / NCT05590676
Metformin Treatment in Infants After Perinatal Brain Injury
Phase 1
Terminated
1 enrolled
The Hospital for Sick Children
University of Alberta · collabUniversity of Waterloo · collab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
A phase I study to test the feasibility and safety of treatment with metformin in infants affected by hypoxic ischemic encephalopathy (HIE) or prematurity-related brain injury
Timeline
- Start
- 2023-05-02
- Primary completion
- 2024-02-22
- Completion
- 2024-02-22
Outcome
Outcome not reported
Stopped (Enrollment): “Low recruitment”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Metformin | Small molecule | 15 mg/kg | — |
| Subject | Metformin | Small molecule | 20 mg/kg | — |
| Subject | Metformin | Small molecule | 25 mg/kg | — |