drugset / Trial / NCT05590923
Steroid-sparing Therapy (Olanzapine) Versus Dexamethasone-based Therapy for Chemotherapy-induced Nausea and Vomiting
RandomizedCrossoverOpen-labelPrevention
Summary
The purpose of this research is to compare two drugs that are routinely used as standard of care for treating nausea and vomiting caused by chemotherapy. This study aims to see if the drug olanzapine is as good as the steroid drug dexamethasone for preventing nausea and vomiting after chemotherapy. Both drugs are listed as appropriate treatment options in the most recent version of National Comprehensive Cancer Network guidelines on Antiemesis.
Timeline
- Start
- 2022-12-07
- Primary completion
- 2025-07-08
- Completion
- 2025-07-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexamethasone | Small molecule | 8 mg | Oral |
| Subject | Olanzapine | Small molecule | 10 mg | Oral |