Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Summary

Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers. The investigators propose to collect such objective data on the frequency of drug resistance and whether any problems with local anesthesia are due to initial ineffectiveness or due to its effects dissipating too soon.

Timeline

Start

2022-11-10

Primary completion

2027-01

Completion

2027-06

Publications

• Bourne KM, Thai S, Lei LY, Siddiqui T, Black B, Peltier A, Paranjape S, Shibao CA, Biaggioni I, Diedrich A, Gamboa A, Okamoto L, Sheldon RS, Raj SR. Patients with Ehlers-Danlos syndrome experience reduced effectiveness of lidocaine local anesthetic: a randomized cross-over clinical trial. Reg Anesth Pain Med. 2026 Mar 3:rapm-2025-107416. doi: 10.1136/rapm-2025-107416. Online ahead of print.

Drugs

Indications