High FODMAP Diet With Metformin in preDM

Summary

This is a prospective, double blinded, randomised cross over feeding trial examine high or low FODMAP diet in combination with metformin on postprandial glucose responses and gastrointestinal tolerability and gut microbiota profiles. The trial will compare high or low FODMAP diet, each of 10 days duration in combination with 5 days metformin, separated by a washout period of at least 2 weeks.

Timeline

Start

2022-11-11

Primary completion

2023-08-25

Completion

2023-10-15

Publications

• Chu NHS, Ling J, Poon EWM, Lee JYS, Song Q, Zuo Z, Muir J, Chan JCN, Chow E. Combining a diet rich in fermentable carbohydrates with metformin improves glycaemic control and reshapes the gut microbiota in people with prediabetes. Nat Metab. 2025 Aug;7(8):1614-1629. doi: 10.1038/s42255-025-01336-4. Epub 2025 Jul 31.

Drugs

Indications