Migraine Induction Properties of PACAP-38 After Eptinezumab in Migraine Without Aura Patients.

Summary

To investigate whether administration of calcitonin gene-related peptide (CGRP) binding monoclonal antibodies eptinezumab prevents pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) induced migraine attacks in migraine without aura patients.

Timeline

Start

2023-03-01

Primary completion

2023-08-04

Completion

2023-08-04

Publications

• Al-Karagholi MA, Zhuang ZA, Beich S, Ashina H, Ashina M. PACAP38-induced migraine attacks are independent of CGRP signaling: a randomized controlled trial. J Headache Pain. 2025 Apr 14;26(1):79. doi: 10.1186/s10194-025-02022-2.

Drugs

Indications