drugset / Trial / NCT05666765
Comparison Between Isotretinoin, Silymarin and Both in the Treatment of Acne Vulgaris
RandomizedParallel-groupOpen-labelTreatment
Summary
This study aims to compare the effects of isotretinoin and silymarin or both in treatment of acne and their effects on the level of IGF-1, SAA1 and malondialdehyde (MDA) in acne patients.
Timeline
- Start
- 2023-01-01
- Primary completion
- 2023-11-01
- Completion
- 2024-01-01
Publications
- Background Hazarika N. Acne vulgaris: new evidence in pathogenesis and future modalities of treatment. J Dermatolog Treat. 2021 May;32(3):277-285. doi: 10.1080/09546634.2019.1654075. Epub 2019 Aug 29.
- Background Shie Morteza M, Hayati Z, Namazi N, Abdollahimajd F. Efficacy and safety of oral silymarin in comparison with oral doxycycline and their combination therapy in the treatment of acne vulgaris. Dermatol Ther. 2019 Nov;32(6):e13095. doi: 10.1111/dth.13095. Epub 2019 Oct 21.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Isotretinoin | Other / unclassified | 20 mg | Oral |
| Subject | Silymarin | Traditional medicine (herbal / TCM) | 140 mg | — |