drugset / Trial / NCT05671172
Effect of Adding Hyaluronidase to Bupivacaine in Transversus Abdominis Plane Block for Cesarean Section
RandomizedParallel-groupDouble-blindPrevention
Summary
Since TAP block needs to affect several nerves in single tissue plane with a single prick, hyaluronidase is expected to aid greatly in the spread of the LA and help the block. However, there have not been adequate studies to establish the efficacy of adding hyaluronidase in lateral TAP after cesarean section. Hence, the present study was carried out to evaluate the efficacy of hyaluronidase in different concentrations added to bupivacaine in US-guided bilateral lateral TAP block.
Timeline
- Start
- 2023-05-15
- Primary completion
- 2024-01-10
- Completion
- 2024-02-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | rHuPH20 | Protein / enzyme biologic | 750 iu | Other |
| Subject | rHuPH20 | Protein / enzyme biologic | 1500 iu | Other |
| Comparator | Bupivacaine | Other / unclassified | 19 ml | Other |
| Comparator | Bupivacaine | Other / unclassified | 20 ml | Other |
Indications
No indication recorded.