Goal-directed Analgesia Using ANI During General Anesthesia in Children With Moyamoya Disease

Summary

Analgesia Nociception Index (ANI) has been proposed for the evaluation of the nociception-antinociception balance in the perioperative period. In pediatric patients with Moyamoay disease, where the management of analgesia may be rendered difficult by pharmacological changes, we hypothesised that the monitoring of analgesia with ANI would reduce intraoperative opioid consumption during EDAS surgery.

Timeline

Start

2023-01-04

Primary completion

2025-01-04

Completion

2025-01-04

Outcome

Met primary endpoint

paper The Analgesia Nociception Index group showed lower intra-operative sufentanil consumption PMID 38832435 ↗

paper mean difference, -0.09; 95% confidence interval, -0.19 to 0.00; P  = 0.049 PMID 38832435 ↗

Publications

• Park JB, Kang P, Ji SH, Jang YE, Lee JH, Kim JT, Kim HS, Kim EH. Effects of goal-directed analgesia using the analgesia nociception index in children undergoing surgery for moyamoya disease: A randomised controlled trial. Eur J Anaesthesiol. 2024 Sep 1;41(9):649-656. doi: 10.1097/EJA.0000000000002013. Epub 2024 Jun 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sufentanil	Other / unclassified	—	Other

Indications

No indication recorded.