Evaluation of the Effect of Systemic Proteolytic Enzyme Therapy on Postoperative Inflammatory Response and QoL After Surgical Extraction of Impacted Mandibular Third Molars
Summary
1. To compare the postoperative pain between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day. 2. To compare the postoperative swelling (edema) between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day. 3. To compare the degree of trismus between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day. 4. Measure patients' perceptions of changes in their quality of life in the postoperative period and compare it between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day.
Timeline
- Start
- 2024-05-08
- Primary completion
- 2024-09-01
- Completion
- 2024-09-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Bromelain | Protein / enzyme biologic | 90 mg | — |
| Comparator | Rutoside | Other / unclassified | 100 mg | — |
| Comparator | TRYPSIN, CRYSTALLIZED | Protein / enzyme biologic | 48 mg | — |
| Comparator | Acetaminophen | Small molecule | 1000 mg | — |
| Comparator | Amoxicillin | Other / unclassified | 500 mg | — |
| Comparator | Metronidazole | Small molecule | 500 mg | — |
Indications
No indication recorded.