drugset

drugset / Trial / NCT05694221

Drug Drug Interaction (DDI) Between Supaglutide and Digoxin or Metformin

NCT05694221 ↗

Phase 1 Completed 34 enrolled Shanghai Yinnuo Pharmaceutical Technology Co., Ltd. Huashan Hospital · collab

Non-randomizedSequentialOpen-labelBasic science

Summary

This is a study of a drug drug interaction between Supaglutide and Digoxin or Metformin.

Timeline

Start: 2023-03-20
Primary completion: 2023-06-06
Completion: 2023-08-17

Publications

Wu X, He J, Wu J, Liu W, Xu Y, Li Y, Zhang J, Wang Q. Effect of Efsubaglutide Alfa on the Pharmacokinetics of Metformin and Digoxin in Healthy Participants. Clin Pharmacokinet. 2025 Sep;64(9):1367-1377. doi: 10.1007/s40262-025-01541-0. Epub 2025 Jun 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Digoxin	Other / unclassified	0.25 mg	Oral
Subject	Metformin	Small molecule	500 mg	Oral
Subject	Supaglutide	Unknown	3 mg	Subcutaneous

Indications

No indication recorded.