SODium BICarbonate for Metabolic Acidosis in the ICU

Summary

This trial aims to assess if, among adults in the ICU with metabolic acidosis, an infusion of sodium bicarbonate diluted in 5% dextrose, compared with an infusion of 5% dextrose, reduces Major Adverse Kidney Events within 30 days of randomization.

Timeline

Start

2023-04-26

Primary completion

2026-01-08

Completion

2026-07

Outcome

Missed primary endpoint

paper The use of sodium bicarbonate in critically ill patients with metabolic acidosis receiving vasopressors did not lead to a lower risk of major adverse kidney events within 30 days than placebo. PMID 42283370 ↗

Publications

• SODa-BIC Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group; Serpa Neto A, McNamara M, White K, Cooper DJ, Fujii T, Higgins AM, Hodgson CL, Navarra L, Nichol A, Peake S, Rea-Neto A, Secombe P, Osborne F, Burrill H, See E, Young M, Zampieri FG, Plummer M, Christie C, Nunnink L, Mackay J, McGuinness S, Marmol J, Tiruvoipati R, Bailey M, Young PJ, Bellomo R, Udy A. Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock. N Engl J Med. 2026 Jun 12. doi: 10.1056/NEJMoa2600526. Online ahead of print.
• Serpa Neto A, McNamara M, Cooper J, Fujii T, Higgins A, Hodgson C, Navarra L, Nichol A, Peake S, Rea-Neto A, Secombe P, See E, Taylor P, Young M, Zampieri FG, Young P, Bellomo R, Udy A; SODa-BIC investigators. Protocol summary and statistical analysis plan for the sodium bicarbonate for metabolic acidosis in the intensive care unit (SODa-BIC) trial. Crit Care Resusc. 2025 May 15;27(2):100108. doi: 10.1016/j.ccrj.2025.100108. eCollection 2025 Jun.

Drugs

Indications