drugset / Trial / NCT05768360
A Study to Assess the Effects of Savolitinib on the Pharmacokinetics of Digoxin, Rosuvastatin, Metformin, and Furosemide in Healthy Male Subjects
NaSequentialOpen-labelOther
Summary
This study will assess the effects of savolitinib on the pharmacokinetics (PK) of substrates of human transporters digoxin (P-gp), rosuvastatin (OATP1B1/3), metformin (OCT2, MATE1/2K), and furosemide (OAT1/3) in healthy male subjects, performed at a single clinical unit.
Timeline
- Start
- 2023-04-25
- Primary completion
- 2023-06-24
- Completion
- 2023-06-24
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Digoxin | Other / unclassified | — | Oral |
| Subject | Furosemide | Other / unclassified | — | Oral |
| Subject | Metformin | Small molecule | — | Oral |
| Subject | Rosuvastatin | Small molecule | — | Oral |
| Subject | Savolitinib | Small molecule | — | Oral |
Indications
No indication recorded.