drugset / Trial / NCT05769530

Advanced Analgesia on the Quality of Recovery After General Anesthesia in Elderly Patients

NCT05769530

Phase 4 Completed 360 enrolled Lili Jia
RandomizedParallel-groupDouble-blindSupportive care

Summary

Recovery period of general anesthesia refers to the period from the end of anesthesia infusion to recovery of the patient after the operation. In patients with general anesthesia, the depth of anesthesia is reduced in the early stage of recovery, the cerebral cortex is still in a state of inhibition, and the subcortical center is often in a state of high sensitivity to external stimulation. At this time, due to drug effects, pain, hypoxemia, undetected aspiration, pneumothorax, urinary retention, tracheal catheter stimulation, urinary tube stimulation and other factors, the patient will be induced to appear restless reaction, and cause drastic changes in hemodynamics. Especially for the elderly with organ dysfunction, it may increase postoperative complications, prolong hospital stay and increase hospital costs.

Timeline

Start
2023-05-01
Primary completion
2025-05-31
Completion
2025-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Dexmedetomidine Other / unclassified 0.5 ug/kg Intravenous
Subject Nalbuphine Small molecule 0.2 mg/kg Intravenous

Indications

No indication recorded.