drugset / Trial / NCT05774067

Noradrenaline Versus Glypressin for Prevention of Hypotension After Deflation of Tourniquet in Knee Arthroplasty

NCT05774067

Completed 135 enrolled Tanta University
RandomizedParallel-groupTriple-blindPrevention

Summary

Pneumatic tourniquet is usually used in orthopedic surgeries, as it helps to decrease operative bed bleeding, and thus, maintaining a clean and dry surgical field allowing easy and clear identification of the anatomical structures. Despite that advantage, after its deflation, there is a blood volume shift towards that ischemic area, which may decrease cardiac preload leading to hypotension

Timeline

Start
2022-12-01
Primary completion
2023-06-30
Completion
2023-07-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Norepinephrine Other / unclassified 0.1 ug/kg
Comparator Terlipressin Peptide 2 ug/kg

Indications