drugset / Trial / NCT05774067
Noradrenaline Versus Glypressin for Prevention of Hypotension After Deflation of Tourniquet in Knee Arthroplasty
RandomizedParallel-groupTriple-blindPrevention
Summary
Pneumatic tourniquet is usually used in orthopedic surgeries, as it helps to decrease operative bed bleeding, and thus, maintaining a clean and dry surgical field allowing easy and clear identification of the anatomical structures. Despite that advantage, after its deflation, there is a blood volume shift towards that ischemic area, which may decrease cardiac preload leading to hypotension
Timeline
- Start
- 2022-12-01
- Primary completion
- 2023-06-30
- Completion
- 2023-07-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Norepinephrine | Other / unclassified | 0.1 ug/kg | — |
| Comparator | Terlipressin | Peptide | 2 ug/kg | — |