drugset / Trial / NCT05779423

Cryoablation+Ipilimumab+Nivolumab in Melanoma

NCT05779423 ↗

Phase 2 Recruiting 37 enrolled Massachusetts General Hospital
NaSingle-groupOpen-labelTreatment

Summary

The aim of this study is to find out whether the combination of two approved drugs, ipilimumab and nivolumab, in combination with cryoablation are safe and effective for participants who have an unresectable melanoma that is resistant, or is growing, after receiving immunotherapy with a PD-1 inhibitor. The names of the study interventions involved in this study are: * Cryoablation (an interventional radiology procedure that freezes part of a tumor) * Ipilimumab (an immunotherapy) * Nivolumab (an immunotherapy)

Timeline

Start
2023-09-23
Primary completion
2028-01-01
Completion
2028-01-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Ipilimumab Monoclonal antibody — Intravenous
Subject Nivolumab Monoclonal antibody — Intravenous