Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer

Summary

Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer (DTC). The traditional first line treatment for patients with advanced DTC after surgical resection is radioactive iodine (RAI) therapy. However, less than a quarter of patients with lung metastases will achieve a complete response to RAI therapy, and this therapy carries the risk of pulmonary fibrosis and an increasingly recognized risk of secondary malignancies.

Timeline

Start

2024-02-14

Primary completion

2026-10-01

Completion

2027-10-01

Drugs

Indications