Effect of Preemptive Etoricoxib and Dexamethasone on Wound Healing and Clinical Parameters After Third Molar Surgery

Summary

The goal of this clinical trial is to compare preemptive single-dose selective cyclooxygenase 2 (COX-2) inhibitor - etoricoxib and dexamethasone use in systemically healthy patients during the surgical extraction of impacted mandibular third molars. The main questions it aims to answer/evaluate are: * the level of inflammatory and early wound healing mediators in patients' saliva during early postoperative phase * clinical postoperative parameters such as pain, swelling and trismus * patient satisfaction with the treatment * rescue medication consumed during the postoperative period * incidence of adverse events Participants indicated for mandibular third molar surgery will be asked to: * take premedication (etoricoxib or dexamethasone) before surgical extraction * provide saliva samples before and following the surgery at regular check-ups * note the amount of rescue medication taken and pain intensity in different time points * perform clinical measurements of swelling and trismus at regular check-up visits * answer the questions about satisfaction and potential adverse events, if occur Researchers will compare preemptive single-dose etoricoxib, preemptive single-dose dexamethasone, and no premedication in impacted mandibular third molar surgery, to see if there are differences in inflammatory response and early wound healing, as well as in clinical postoperative parameters, patient satisfaction with the treatment and incidence of potential adverse events.

Timeline

Start

2021-10-11

Primary completion

2022-12-26

Completion

2022-12-26

Publications

• Background Martins-de-Barros AV, Barros AM, Siqueira AK, Lucena EE, Sette de Souza PH, Araujo FA. Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. Med Oral Patol Oral Cir Bucal. 2021 Mar 1;26(2):e141-e150. doi: 10.4317/medoral.24088.
• Mijailovic I, Janjic B, Milicic B, Todorovic A, Ilic B, Misic T, Markovic N, Markovic A. Comparison of preemptive etoricoxib and dexamethasone in third molar surgery - a randomized controlled clinical trial of patient-reported and clinical outcomes. Clin Oral Investig. 2023 Sep;27(9):5263-5273. doi: 10.1007/s00784-023-05146-4. Epub 2023 Jul 14.

Drugs

Indications

No indication recorded.