0.9% Saline Versus Balanced Solutions in Severe Diabetic Ketoacidosis

Summary

Severe diabetic ketoacidosis (DKA) is a potentially serious complication of diabetes mellitus. The treatment regimen is based on insulin and rehydration. The choice of rehydration solution is a question that remains open. We sought to compare the effect of sodium chloride 0.9% (SC) versus ringer lactate (RL) in the resolution of severe DKA as well as on the variation of electrolytes.

Timeline

Start

2022-11-01

Primary completion

2023-12-30

Completion

2023-12-30

Publications

• Trifi A, Ben Braik I, Galai H, Azzouz N, Tlili B, Mehdi A, Messaoud L, Seghir E, Ouhibi A, Abdellatif S. 0.9% sodium chloride versus ringer's lactate in the management of severe diabetic ketoacidosis: A randomized trial. Med Intensiva (Engl Ed). 2026 Apr;50(4):502203. doi: 10.1016/j.medine.2025.502203. Epub 2025 Apr 14.

Drugs

Indications