Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa

Summary

Many RCT(randomized controlled trial) studies reported that tranexamic acid reduced blood loss in women who had elective cesareans. However, most of these elective cesareans are without high-risk factors of postpartum hemorrhage, such as placenta previa. The prophylactic use of tranexamic acid in the placenta previa is not clear. studies had poor quality and lacked adequate power to assess severe adverse events.

Timeline

Start

2023-07-12

Primary completion

2025-02-11

Completion

2025-03-23

Publications

• Zhang L, Bi S, Chen L, Du L, He F, Qiao Y, Li Z, Zeng W, Zhao X, Chen X, Li X, Ding G, Zhou W, Sun B, Guo Q, Guo X, Jin F, Wang X, Zhu Q, Sun Q, Jiang S, Wang X, Cai F, Jiang Y, Gao J, Wang Z, Wang Z, Zhang L, Liu JM, Huang L, Yu L, Chen J, Zhang S, Poon LC, Li HT, Chen D; study's collaborator group. Prophylactic tranexamic acid for the prevention of postpartum haemorrhage in women with placenta praevia: multicentre, double blind, randomised, placebo controlled, phase 3 trial. BMJ. 2026 May 13;393:e089636. doi: 10.1136/bmj-2026-089636.
• Zhang L, Hu M, Bi S, Poon LC, He F, Li H, Zhang Y, Gu Z, Wang Z, Du L, Chen D; TRAPP Study Group. TRAPP- Protocol for Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa. Matern Fetal Med. 2026 Jan;8(1):3-12. doi: 10.1097/FM9.0000000000000297. Epub 2025 Jul 15.

Drugs

Indications