Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity
Summary
Most research to date on bariatric surgery outcomes has been about metabolic syndrome, a disorder very effectively treated by bariatric surgery. However, obesity is also associated with many other problems that have received much less attention. Amongst the most troubling of these for patients is dyspnea. Dyspnea results in substantial patient distress that can greatly reduce health-related quality of life. Little is known about the relationship between dyspnea, weight loss, and bariatric surgery. Dyspnea is a complex symptom that may lead to adaptive responses, such as the need to rest as a consequence of even minimal activity or seeking medical attention. The main outcome of the study will be measured using a new state-of-the-science validated HRQOL measure, the Patient Reported Outcome Measuring Information System for Heart Failure (PROMIS+HF 27).
Timeline
- Start
- 2023-07-09
- Primary completion
- 2025-02-12
- Completion
- 2025-02-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Contrave | Unknown | — | — |
| Background | Liraglutide | Peptide | — | — |
| Background | Orlistat | Small molecule | — | — |
| Background | Semaglutide | Peptide | — | — |
| Background | Setmelanotide | Protein / enzyme biologic | — | — |
| Background | Tirzepatide | Peptide | — | — |
| Background | VI-0521 | Unknown | — | — |
Indications
No indication recorded.