drugset / Trial / NCT05816785
Pilot Study of Imatinib Cetuximab Combo for H & N Cancer
Phase 0
Active not recruiting
15 enrolled
University of Wisconsin, Madison
National Cancer Institute (NCI) · collab
NaSingle-groupOpen-labelTreatment
Summary
The goal of this clinical trial is to find if levels of a protein called AXL in tumor cells relate to how tumors respond to cetuximab (CTX) combined with imatinib in participants with head and neck cancer. This interventional study will occur in the time between diagnosis of your cancer and surgery to remove your tumor or radiation or chemoradiation treatment of your primary cancer. Participants will undergo a research blood draw and a research biopsy as part of the screening process, and will be in this research study for approximately 13 to 16 months.
Timeline
- Start
- 2023-04-18
- Primary completion
- 2026-10-31
- Completion
- 2026-10-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cetuximab | Monoclonal antibody | 250 mg/m2 | — |
| Subject | Imatinib | Small molecule | 400 mg | Oral |