drugset / Trial / NCT05832398
Precision Chemotherapy Based on Organoid Drug Sensitivity for Colorectal Cancer
Unknown
186 enrolled
Nanfang Hospital, Southern Medical University
Sixth Affiliated Hospital, Sun Yat-sen University · collabSun Yat-sen University · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to investigate whether chemotherapy guided by patient-derived tumor organoid drug test can improve the outcomes of stage IV colorectal cancer.
Timeline
- Start
- 2023-05-01
- Primary completion
- 2025-01-01
- Completion
- 2025-12-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Capecitabine | Small molecule | 1000 mg/m2 | Oral |
| Subject | Irinotecan | Small molecule | 150 mg/m2 | — |
| Subject | Leucovorin | Small molecule | 400 mg/m2 | — |
| Subject | Oxaliplatin | Small molecule | 85 mg/m2 | Intravenous |
| Subject | Oxaliplatin | Small molecule | 130 mg/m2 | Intravenous |
| Subject | fluorouracil | Small molecule | 400 mg/m2 | — |
| Subject | fluorouracil | Small molecule | 2400 mg/m2 | — |
| Subject | fluorouracil | Small molecule | 3200 mg/m2 | — |