Antenatal Dexamethasone for Late Preterm Deliveries

Summary

The goal of this clinical trial is to compare dexamethasone in late preterm deliveries. The main questions it aims to answer are: Does antenatal dexamethasone reduce the need for respiratory support in late preterm infants? Does antenatal dexamethasone reduce neonatal morbidities and mortality? Does antenatal dexamethasone reduce admission to Neonatal Intensive Care Unit and length of hospital stay? Participants will be allocated into 2 groups: intervention with dexamethasone IM and control (standard care). Investigators will compare these two groups to see if antenatal dexamethasone reduces the need for respiratory support in late preterm infants, neonatal morbidities and mortality, admission to NICU and length of hospital stay.

Timeline

Start

2023-08-25

Primary completion

2024-03-28

Completion

2024-04-30

Outcome

Met primary endpoint

paper Infants in the control group required respiratory support after birth more frequently than those in the dexamethasone group (24.5% vs. 15%, p = 0.04). PMID 41452963 ↗

Publications

• Le CHM, Tran HT, Huynh QK, Chaithongwongwatthana S. Impact of Antenatal Dexamethasone on Respiratory Outcomes in Late Preterm Infants in a Vietnamese Tertiary Hospital: A Randomised Controlled Trial. Acta Paediatr. 2026 Apr;115(4):887-893. doi: 10.1111/apa.70417. Epub 2025 Dec 26.

Drugs

Indications