Tranexamic Acid in Debridement Surgery of Burns on the Volume of Bleeding in Transfusion Requirements

Summary

Tranexamic acid in debridement surgery of burns on the volume of bleeding in transfusion requirements

Timeline

Start

2022-01-01

Primary completion

2022-01-01

Completion

2023-12-30

Publications

• Background Dominguez A, Alsina E, Landin L, Garcia-Miguel JF, Casado C, Gilsanz F. Transfusion requirements in burn patients undergoing primary wound excision: effect of tranexamic acid. Minerva Anestesiol. 2017 Apr;83(4):353-360. doi: 10.23736/S0375-9393.16.10992-7. Epub 2016 Nov 9.
• Background K S A, Kumar P, Subair M, Sharma RK. Effect of single dose intravenous tranexamic acid on blood loss in tangential excision of burn wounds - A double blind randomised controlled trial. Burns. 2022 Sep;48(6):1311-1318. doi: 10.1016/j.burns.2021.08.021. Epub 2021 Aug 30.
• Background Brown NJ, Choi EH, Gendreau JL, Ong V, Himstead A, Lien BV, Shahrestani S, Ransom SC, Tran K, Tafreshi AR, Sahyouni R, Chan A, Oh MY. Association of tranexamic acid with decreased blood loss in patients undergoing laminectomy and fusion with posterior instrumentation: a systematic review and meta-analysis. J Neurosurg Spine. 2021 Nov 5;36(4):686-693. doi: 10.3171/2021.7.SPINE202217. Print 2022 Apr 1.
• Results Tapking C, Hundeshagen G, Kirchner M, Fischer S, Kneser U, Bliesener B. Tranexamic acid reduced blood transfusions in acute burn surgery: A retrospective case-controlled trial. Burns. 2022 May;48(3):522-528. doi: 10.1016/j.burns.2022.03.002. Epub 2022 Mar 16.
• Castillo-Cardiel G, Avalos-Lopez M, Mendez-Miranda C, Gil-Vigna JA, Fuentes-Orozco C, Cervantes-Guevara G, Cervantes-Perez E, Ramirez-Ochoa S, Alvarez-Villasenor AS, Cortes-Flores AO, Morfin-Meza KD, Garcia A, Vazquez-Sanchez SJ, Gonzalez-Ojeda A. Comparative efficacy of tranexamic acid versus placebo on hemostatic outcomes after the surgical debridement of burn patients: A randomized controlled clinical trial. Burns. 2025 Mar;51(2):107339. doi: 10.1016/j.burns.2024.107339. Epub 2024 Nov 30.

Drugs

Indications

No indication recorded.