A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Summary

The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.

Timeline

Start

2023-06-19

Primary completion

2025-12-08

Completion

2027-01-01

Outcome

Missed primary endpoint

paper There was no statistically significant effect of fentanyl on ΔE range (P=0.432). PMID 42414111 ↗

Publications

• Gransee HM, Urban MW, Martin BA, Stoltenberg AD, Knoll KM, Jahanian S, Anderson BK, Panchamia JK, Schroeder DR, Mantilla CB. Effects of fentanyl on diaphragm muscle force in patients undergoing knee arthroplasty: a randomised double-blind clinical trial. Br J Anaesth. 2026 Jul 7:S0007-0912(26)00418-6. doi: 10.1016/j.bja.2026.06.004. Online ahead of print.

Drugs

Indications