Effect of Mesenchymal Stem Cells-derived Exosomes in Decompensated Liver Cirrhosis

Summary

Decompensated liver cirrhosis (LC), a life-threatening complication of chronic liver disease, is one of the major indications for liver transplantation. Recently, mesenchymal stem cell (MSC) transfusion has been shown to lead to the regression of liver fibrosis in mice and humans. However, little is known about MSC-exosome therapy. We will evaluate the therapeutic potential of mesenchymal stem Cell-Exosomes as an alternative to cell therapy in Cirrhotic patients. This study examined the safety and efficacy of umbilical cord-derived MSC-exosomes in patients with decompensated LC.

Timeline

Start

2023-05-26

Primary completion

2023-08-11

Completion

2023-12-11

Drugs

Indications