Drugs / MSC-derived exosomes
MSC-derived exosomes
Trials 5
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 02 trials | ||||||
| Phase 0 | NCT05808400 | Feb 2023 → Feb 2024 | long COVID-19 | Huazhong University of Science and Technology | Unknown | No outcome recorded |
| Phase 0 | NCT07146087 | Jul 2020 → Jun 2023 | multiple sclerosis | Biocells Medical | Suspended | No outcome recorded |
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT07508033 | Jan → Jul 2026 overdue | periodontal disorder | Al Salam University | Recruiting | No outcome recorded |
| Phase 1/2 | NCT05669144 | Apr 2022 → Sep 2023 | myocardial ischemia, myocardial stunning | Tehran University of Medical Sciences | Unknown | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT05871463 | May → Aug 2023 | cirrhosis of liver | Research Institute for Gastroenterology and Liver Diseases (RIGLD) | Unknown | No outcome recorded |
News releases announcing trial results or a regulatory action · 1
| Date | Issuer | Release |
|---|---|---|
| 2021-01-20 | Brainstorm-Cell Therapeutics | Results BrainStorm Announces the Publication of Preclinical Data Highlighting the Potential of a NurOwn® Derived Exosome-Based Treatment for COVID-19 ARDS brainstorm-cell.com ↗
Notably, these improvements were significantly superior to those observed following administration of naïve MSC-derived exosomes. |
All press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2021-01-20 | Brainstorm-Cell Therapeutics | BrainStorm Announces the Publication of Preclinical Data Highlighting the Potential of a NurOwn® Derived Exosome-Based Treatment for COVID-19 ARDS brainstorm-cell.com ↗ |
Evidence & citations 8 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | MSC-derived exosomes | “Group A (Intervention): Following atraumatic extraction, MSC-derived exosomes are applied to the extraction socket.” NCT07508033 ↗ |
| Known as | Mesenchymal Stem Cell (MSC)-derived exosomes | “This is a randomized, single-blind, controlled clinical trial designed to compare the regenerative potential of Mesenchymal Stem Cell (MSC)-derived exosomes versus Autologous...” NCT07508033 ↗ |
| Known as | MSC-Exosomes | “Experimental Group (MSC-Exosomes)” NCT07508033 ↗ |
| Known as | UCMSC-derived exosomes | “Participants will receive either continuous nebulized inhalation of UCMSC-derived exosomes for 5 days, twice daily, or no treatment.” NCT05808400 ↗ |
| Known as | UCMSC-derived extracellular vesicle | “This clinical trial aims to evaluate the safety and effectiveness of umbilical cord mesenchymal stem cell (UCMSC)-derived extracellular vesicle nebulization inhalation therapy...” NCT05808400 ↗ |
| Known as | umbilical cord mesenchymal stem cell-derived extracellular vesicles (EVs) | “Treated with umbilical cord mesenchymal stem cell-derived extracellular vesicles (EVs) preparation (Specification: 5ml, EV concentration of 1\*10\^9 particles /ml)” NCT05808400 ↗ |
| Modality | Other / unclassified | “umbilical cord mesenchymal stem cell-derived extracellular vesicles (EVs) preparation” NCT05808400 ↗ |
| Route | Other | “Mitochondrial and exosome transplantation by intracoronary and intra-myocardial injection.” NCT05669144 ↗ |