Prevention of Bleeding in Total Joint Replacement: Combined Route Administration of Tranexamic Acid

Summary

The investigators aimed to compare two doses of intravenous (IV) tranexamic acid (TXA) with a combined single dose of topical and IV TXA on haemoglobin decline 24 hours after total joint arthroplasties. The investigators conducted randomized, double-blind trial. The participants were randomized to either intrvenous group receiving 2 doses of 1 gram TXA in intravenous route 3 hours apart, or a combined application group receiving the first 1 gram IV and the topical dose was 1.5 gram after reduction of the fascia.

Timeline

Start

2021-12-01

Primary completion

2022-09-30

Completion

2022-12-31

Drugs

Indications