Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab

Summary

An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine. Here, we hypothesize that experimentally-induced dilation of intracranial arteries using intake of sildenafil (a potent vasodilator) can induce cephalic pain with migraine-like features in people with migraine, who prior to the infusion are administered erenumab (anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody.

Timeline

Start

2023-04-20

Primary completion

2023-10-12

Completion

2023-10-12

Publications

• Raffaelli B, Do TP, Ashina H, Snellman J, Maio-Twofoot T, Ashina M. Induction of cGMP-mediated migraine attacks is independent of CGRP receptor activation. Cephalalgia. 2024 Jun;44(6):3331024241259489. doi: 10.1177/03331024241259489.

Drugs

Indications